The Rental Car Center at Sky Harbor International Airport in Phoenix is open 24 hours, seven days per week. Most rental car companies renting cars at the airport are also 24-hour operations, but the ones that are not will have some way for you to securely drop off your car keys if you happen to be there during nonpeak hours.
To be certain, you might want to call the car rental company itself to verify that an agent will be on duty when you want to return your car. Here are the direct phone numbers for the car rental companies at the Phoenix airport rental center.
All of Sky Harbor's rental car companies are required to be open one hour before the first flight and one hour past the last arrival.
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